Endocrine Abstracts

Background: Persons with assigned either male (AMAB) or female (AFAB) sex at birth might wish to obtain feminization or masculinization, respectively. To this purpose, hormonal treatment with sex hormones must be tailored to each subject. Several studies and the European Society of Endocrinology guidelines tried to identify the optimal hormonal treatment in both AMAB and AFAB subjects. However, the clinical management in the long term follow-up remains challenging. Many treatm...

Background: Patients with CHH and KS have eunuchoid body proportions of the skeleton compared to normal male subjects, characterized by tall stature, and reduced upper-to-lower segment ratio (U/l). Vice versa, steroids exposure deeply differs between CHH and KS at puberty, with both testosterone and estradiol being very low only in CHH. At present, body skeletal proportions comparison between CHH and KS is not available.Aim: To compare anthropom...

Introduction: Male idiopathic infertility represents a therapeutic challenge for physicians, since a targeted aetiological treatment does not exist. Several hormonal and non-hormonal therapies have been proposed so far to increase pregnancy rates. Among hormonal therapies, exogenous follicle-stimulating hormone (FSH) administration shows the most convincing physiological rationale in the face of a clinical efficacy below expectations. Indeed, from evidences available in the li...

Background: Erectile dysfunction (ED) represents the most frequent sexual dysfunction. Among several possible ED aetiologies, vascular ED (vED) presents the greatest implications for global individual health, resulting an early hallmark of cardiovascular diseases. Indeed, vED was demonstrated associated with a 1.25 times greater risk of developing major cardiovascular diseases. Alongside cardiovascular aspect, the evaluation of patients health, measured by the comorbidities nu...

Background: Exogenous follicle-stimulating hormone (FSH) administration in male idiopathic infertility showed the most convincing rationale in the face of a clinical efficacy below expectations. It was calculated that 10 to 18 men have to be treated to achieve one pregnancy.Objectives: To assess the effectiveness of FSH administration in male idiopathic infertility in a clinical setting.Methods: A retrospective real-world study was...

Background: Patients with CHH and KS share eunuchoid body proportions of skeleton compared to normal male subjects. On the contrary, testosterone levels at puberty are lower in CHH patients compared to KS patients.Aim: To compare anthropometric measurements of adult male CHH vs KS patients.Methods: A prospective, cross-sectional, observational study was conducted. CHH patients were subdivided into 2 subgroups according to the timin...

Background: Erectile dysfunction (ED) is the most frequent sexual disorder. Although psychological ED (pED) is the most frequent form, vascular ED (vED) is associated with 1.25 times greater risk of developing major cardiovascular diseases. Alongside cardiovascular aspect, the evaluation of patients’ health, measured by the comorbidities number, in relation to the ED aetiology has never been investigated so far.Objectives: To explore the potential r...

Objective: Environmental rhythmicity seems able to affect the hypothalamic-pituitary-gonadal axis in animals, but the extent of its influence in humans is still controversial. This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big data approach.Methods: An observational, retrospective, big data trial was carried out, including all testosterone, luteinizing hor...

Obesity is characterized by insulin resistance and pancreatic β-cell dysfunction; moreover, secretion of adipokines from adipocytes may affect metabolic functions in several tissues, including pancreatic β-cells. Extracellular vesicles (EVs), released by cells as exosomes or shedding vesicles, play a key role in cell-to-cell communication, modifying the phenotype and function of recipient cells by delivering proteins, RNAs and microRNAs. The crosstalk between adipocy...

Human malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm, arising from pleural mesothelial cells, generally due to asbestos exposure. Different growth factors are involved in the pathogenesis of MPM and in resistance to therapy; moreover, chemotherapy with cisplatin and antifolates, like pemetrexed (PEM), is the first-line treatment for inoperable MPM. Growth hormone-releasing hormone (GHRH), apart from stimulating GH secretion in the pituitary, exerts many...